The present invention relates to a RTEL1 inhibitor for use in treatment of an HBV infection, in particular a chronic HBV infection. The invention in particular relates to the use of RTEL1 inhibitors for destabilizing cccDNA, such as HBV cccDNA. The invention also relates to antisense oligonucleotides which are complementary to RTEL1 and capable of reducing a RTEL1 mRNA. Also comprised in the present invention is a pharmaceutical composition and its use in the treatment and/or prevention of a HBV infection.本發明係關於一種用於治療HBV感染，尤其慢性HBV感染之RTEL1抑制劑。本發明尤其關於RTEL1抑制劑用於去穩定化諸如HBV cccDNA之cccDNA之用途。本發明亦關於與RTEL1互補且能夠降低RTEL1 mRNA之反義寡核苷酸。本發明亦包含一種醫藥組合物及其用於治療及/或預防HBV感染之用途。
