LTD.;CUK HOLDINGS CO., LTD.;CUK HOLDINGS CO.;가톨릭대학교기술지주 주식회사
发明人:
KIM, TAI GYU,김태규
申请号：
KR1020110037522
公开号：
KR1020120119538A
申请日:
2011.04.21
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
PURPOSE: A tumor antigen protein or gene of polo - like kinase 1 is provided to be function as tumor antigen which can be recognized by cytotoxic T lymphocyte.CONSTITUTION: A tumor antigen protein or gene of polo - like kinase 1 is recognized by cytotoxic T lymphocyte by combining with MHC classIantigen or II antigen. The tumor antigen protein or gene of polo - like kinase 1 includes the polo-like kinase 1 induced sequence number 1 and a derivative having the protein consisting of the amino acid sequence described in the sequence number 3 or a derivative having the functionally identical property as the protein. The polo - like kinase 1 is mouse or human origin. The protein consisting of the amino acid sequence of the sequence number 1 is coded from the gene consisting of the base sequence described in the sequence number 2. The protein consisting of the amino acid sequence described in the sequence number 3 is coded from the gene consisting of the base sequence described in the sequence number 4.COPYRIGHT KIPO 2013본 발명은 폴로-유사 키나아제 1(Polo-like kinase 1) 유래의 종양항원 단백질 또는 유전자에 관한 것으로, 폴로-유사 키나아제 1 유래의 단백질 또는 이들과 기능적으로 동등한 특성을 갖는 유도체가 MHC 클래스Ⅰ 항원 또는 Ⅱ 항원과 결합하여 복합체를 형성함으로써 상기 복합체가 세포독성 T 림프구에 의해 인식될 수 있는 종양항원임을 규명함으로써 범용 종양의 면역치료에 이용할 수 있다.
