CRYSTALLINE FORMS OF (S) 1 (4 (5 CYCLOPROPYL 1H PYRAZOL 3 YLAMINO)PYRROLO [1 2 F] [1 2 4] TRIAZIN 2 YL) N (6 FLUOROPYRIDIN 3 YL) 2 METHYLPYRROLIDINE 2 CARBOXAMIDE

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专利权人:

发明人:

SCHLAM ROXANA F,NG ALICIA TEE FUAY,WEI CHENKOU

申请号：

IN6783/CHENP/2012

公开号：

IN2012CN06783A

申请日:

2012.08.01

申请国别(地区):

IN

年份:

2014

代理人:

摘要：

Crystalline forms of (S) 1 (4 (5 cyclopropyl 1H pyrazol 3 ylamino)pyrrolo[1 2 f][1 2 4]triazin 2 yl) N (6 fluoropyridin 3 yl) 2 methylpyrrolidine 2 carboxamide of the formula (I)are provided. Also provided is a pharmaceutical composition comprising one or more crystalline forms of (3R 4R) 4 amino 1 [[4 [(3 methoxyphenyl)amino]pyrrolo[2 1 f][1 2 4]triazin 5 yl]methyl]piperidin 3 ol as well as a method of using one or more crystalline forms of (3R 4R) 4 amino 1 [[4 [(3 methoxyphenyl)amino]pyrrolo[2 1 f][1 2 4]triazin 5 yl]methyl]piperidin 3 ol in the treatment of cancer and other proliferative diseases.

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