Robert G.K. Donald,Annaliesa Sybil Anderson,Laurent Oliver Chorro,Jianxin Gu,Jin-Hwan Kim,Srinivas Kodali,Jason Arnold Lotvin,Justin Keith Moran,Rosalind Pan,Avvari Krishna Prasad,Mark Edward Ruppen,S
申请号：
US16534457
公开号：
US20200061177A1
申请日:
2019.08.07
申请国别(地区):
US
年份:
2020
代理人:
摘要：
In one aspect, the invention relates to an immunogenic composition comprising modified O-polysaccharide molecules derived from E. coli lipopolysaccharides and conjugates thereof. Multivalent vaccines may be prepared by combining two or more monovalent immunogenic compositions for different E. coli serotypes. In one embodiment, the modified O-polysaccharide molecules are produced by a recombinant bacterium that includes a wzz gene.
