RAYMOND R. TJANDRAWINATA,AGUNG HERU KARSONO,JAMES M. SINAMBELA,ASEP ARIPIN,OLIVIA MAYASARI,PRISKA HARDADI
申请号：
ARP140102167
公开号：
AR096464A1
申请日:
2014.06.03
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
A preparation comprising a Herbal Extract and / or fraction and a Pharmaceutical Preparation includes extract of Curcuma Mangga val. et zipp., which has bioactivities in the reduction of the levels of expression of 5 - Reductase 1, PI3 and androgen receptor in prostate cancer cells. The use of This relates to the reduction of Prostate Enlargement.Moreover, it can also be used to treat Lung Cancer and other diseases related to the Route of GPCR. Claim 1: an extract of Curcuma Mangga val. et. Zipp. And / or its fraction derived from it, where the extract is obtained by a process which comprises the steps of: a) Chop curcuma Mangga val. et Zipp. Dry up to a length of 3 - 7 mm.； (b) remove the chopped material of Step (a) with maceration method using organic Solvent and / or Percolation, where the solid to Solvent ratio is 1: 6) - (1: 10) P / VThe duration of the maceration and / or Percolation is between 30 and 240 minutes and filtered to obtain filtrate Solids； (c) concentrate Filtering STEP (b) by Evaporation to obtain the concentrated extract； (d) add a filling to the concentrated extract of Step (c)； (e) Drying The mixture of concentrated extract and filling Stage (d) to obtain a Dry grinding； (f)Dry extract of Stage (e). Claim 2: The extract and / or fraction that is obtained through a process according to claim 1, wherein the part of Curcuma Mangga val. et. Zipp used in STEP (a) is the Rhizome. Claim 2: The extract and / or fraction.According to claim 1, wherein the extract fraction and / or comprise at least the group of compounds including flavonoids, phenols, saponins, terpenoids, steroids or their combination.Claim 14: a Pharmaceutical composition comprising the extract and / or fraction according to claim 1, as an active ingredient alone or in combination, and a Carrier, or pharmaceutically acceptable excipients and Additives that are physiologically appropriate where the compo As pharmaceutical preparation in the form of Solid, semi-solid or liquid
