The present invention relates to compositions and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid ß toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimer's disease, Alzheimer's disease related disorders, Amyotrophic Lateral Sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury.본 발명은 근위축성 측삭 경화증의 치료를 위한 조성물 및 방법에 관한 것이다. 더욱 구체적으로는, 본 발명은 근위축성 측삭 경화증 및 관련 장애의 치료를 위한 신규한 조합 치료법에 관한 것이다.