MÉTHODE DE PRODUCTION D'UN DÉRIVÉ DE 7H-PYRROLO[2,3-D]PYRIMIDINE, ET CO-CRISTAL DUDIT DÉRIVÉ

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专利权人:

Japan Tobacco; Inc.

发明人:

申请号：

EP17883651.6

公开号：

EP3560931A1

申请日:

2017.12.20

申请国别(地区):

EP

年份:

2019

代理人:

摘要：

The present invention relates to processes for preparing 7H-pyrrolo[2,3-d]pyrimidine derivatives which are useful as a Janus kinase (JAK) inhibitor, co-crystals thereof, processes for preparing the co-crystals, and processes for purifying 7H-pyrrolo[2,3-d]pyrimidine derivatives by employing the co-crystals. The present invention provides, for example, a process for preparing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile by employing a co-crystal of 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile with 3,5-dimethylpyrazole.

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中国工程科技知识中心

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