Christina Furebring;Björn Ulrik Walse;Karin Haraldsson;Erika Gustafsson;Anna Rosén
发明人:
Christina Furebring,Anna Rosén,Karin Haraldsson,Erika Gustafsson,Björn Ulrik Walse
申请号：
US13142835
公开号：
US08552149B2
申请日:
2009.11.30
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention provides a polypeptide having a biological activity of the Chemotaxis Inhibitory Protein of Staphylococcus aureus (‘CHIPS’), the polypeptide comprising or consisting of the amino acid sequence of SEQ ID NO: 2, or a fragment or variant thereof having a biological activity of CHIPS, wherein the fragment or variant retains amino acid substitutions K40E, D42V, N77H, K100R, K105R, N111 K and/or G112A relative to the wildtype CHIPS protein of SEQ ID NO:1. In one embodiment, polypeptide consists of the amino acid sequence of SEQ ID NO: 2. Related aspects of the invention provide pharmaceutical compositions comprising a polypeptide of the invention, together with methods or making and using the same.
