2-(4-Substituted anilino)-1,3-benzoxazole derivatives (I) and their salts, derivatives, solvates and stereoisomers (including mixtures in all proportions) are new. Benzoxazoles of formula (I) and their salts, derivatives, solvates and stereoisomers (including mixtures in all proportions) are new. [Image] R 1>； - R 3>；R, halo, CN, NO 2, NHR, NRR, NHCOR, NHSO 2R, OR, COR, CONHR, CF 3, OCF 3, SCF 3, SO 3R, SO 2R, SO 2NR or COOR； R : H； or A, Ar, Het, (CH 2) qAr or (CH 2) qHet (all optionally substituted (os) by 1-4 R 4>； groups)； A : 1-14C linear, branched or cyclic alkyl (optionally having 1 or 2 CH 2 groups replaced by O, S and/or CH=CH and os by 1-7 F and/or Cl)； A : phenyl, naphthyl or biphenyl (all os by 1-3 of A, halo, OH, OA, CN, NO 2, NH 2, NHA, NA 2, NHCOA, SCF 3, SO 2A, COOH, COOA, CONH 2, CONHA, CONA 2, NHSO 2A, SO 2NH 2, SO 2NHA, SO 2NA 2, CHO or COA)； Het : mono- or bicyclic, saturated, unsaturated or aromatic heterocycle containing 1-4 of N, O and/or S (os by 1-3 of =O, halo, A, -(CH 2) bAr, -(CH 2) b-cycloalkyl, OH, OA, NH 2, NHA, NA 2, NO 2, CN, COOH, COOA, CONH 2, CONHA, CONA 2, NHCOA, NHCONH 2, NHSO 2A, CHO, COA, SO 2NH 2 and/or S(O) gA)； R 4>；halo, OH, CN, NO 2, CF 3, OCF 3, SCF 3, SO 2A or OA； X : O, S, SO 2NH or NH； Y : phenyl or monocyclic heteroaryl with 1-4 N, O and/or S atoms； b : 0-4； g : 0-2； n, m, p, q : 1-4. An independent claim is included for the preparation of (I). ACTIVITY : Cytostatic； ophthalmological； antidiabetic； antiinflammatory； osteopathic； antiarthritic； antipsoriatic； antirheumatic； dermatological； antiallergic； gynecological； vulnerary； immunosuppressive； immunostimulant； antiarteriosclerotic； anti-HIV. MECHANISM OF ACTION : Kinase inhibitor. (5-Chloro-7-nitro-benzoxazol-2-yl)-(4-(pyridin-4-ylsulfanyl)-phenyl)-amine (Ia) had IC 5 0 310 nM for inhibition of TIE-2.
