INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
发明人:
DIMARCHI, RICHARD D,SMILEY, DAVID L,DIMARCHI, MARIA,CHABENNE, JOSEPH,DAY, JONATHAN,PATTERSON, JAMES,WARD, BRIAN C
申请号：
NZ58984709
公开号：
NZ589847A
申请日:
2009.06.16
申请国别(地区):
NZ
年份:
2013
代理人:
摘要：
589847 Provided is a glucagon peptide, or a pharmaceutically acceptable salt thereof, comprising a specified amino acid sequence, with up to nine amino acid modifications, wherein the amino acid at position 10 of the glucagon peptide is acylated or alkylated with a C4 to C30 fatty acid and wherein the amino acid at position 16 of the glucagon peptide is an ?, ?-disubstituted amino acid, wherein said glucagon peptide exhibits enhanced activity at the GLP-1 receptor as compared to native glucagon. The peptide can be used to treat diabetes or obesity.
