The subject matter described herein is directed to immunogenic compositions comprising (i) a recombinant Listeria strain comprising a nucleic acid comprising a first open reading frame encoding a fusion polypeptide, wherein the fusion polypeptide comprises a PEST-containing peptide fused to an antigenic peptide and (ii) an anti-CCR8 antibody or a fragment thereof, and methods of treatment using the compositions. Also provided herein are recombinant fusion polypeptides comprising an antigenic peptideje.g., fused to a PEST-containing peptide). Also provided are nucleic acids encoding such fusion polypeptides, recombinant bacteria or Listeria strains comprising such fusion polypeptides or such nucleic acids, and cell banks comprising such recombinant bacteria or Listeria strains. Also provided herein are methods of generating such fusion polypeptides, such nucleic acids, and such recombinant bacteria or Listeria strains. Also provided are immunogenic compositions, pharmaceutical compositions, and vaccines comprising such fusion polypeptides, such nucleic acids, or such recombinant bacteria or Listeria strains. Also provided are methods of inducing an anti-tumor-associated-antigen immune response in a subject, methods of inducing an anti-tumor or anti-cancer immune response in a subject, methods of treating a tumor or cancer in a subject, methods of preventing a tumor or cancer in a subject, and methods of protecting a subject against a tumor or cancer using such recombinant fusion polypeptides, nucleic acids, recombinant bacteria or Listeria strains, immunogenic compositions, pharmaceutical compositions, or vaccines.La présente invention concerne des compositions immunogènes comprenant (i) une souche de Listeria recombinante comprenant un acide nucléique comportant un premier cadre de lecture ouvert codant pour un polypeptide de fusion, le polypeptide de fusion comprenant un peptide contenant PEST fusionné à un peptide antigénique et (ii) un anticorps anti-CCR8 ou un f
