Georg Jaeschke,Lothar Lindemann,Antonio Ricci,Daniel Rueher,Heinz Stadler,Eric Vieira
申请号：
US14689387
公开号：
US09359301B2
申请日:
2015.04.17
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to ethynyl derivatives of formula IwhereinY is N or CHR1 is fluoro or chloroor to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof.It has now surprisingly been found that the compounds of general formula I are metabotropic glutamate receptor antagonists (negative allosteric modulators) for use in the treatment of anxiety and pain, depression, Fragile-X syndrom, autism spectrum disorders, Parkinson's disease, and gastroesophageal reflux disease (GERD).
