Protein kinase conjugates and inhibitors

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专利权人:

Celgene Avilomics Research; Inc.

发明人:

Juswinder Singh,Russell Colyn Petter,Deqiang Niu,Lixin Qiao,Arthur Kluge,Roy Lobb,Shomir Ghosh,Zhendong Zhu

申请号：

US15213319

公开号：

US10662195B2

申请日:

2016.07.18

申请国别(地区):

US

年份:

2020

代理人:

摘要：

The invention relates to protein conjugates that contain a protein kinase containing a cysteine residue in the ATP binding site and an inhibitor that is covalently and irreversibly bonded to said cysteine residue, such that the activity of the protein kinase is irreversibly inhibited. The invention also relates to compounds that irreversibly inhibit protein kinases.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/