XIAOLING GAO,MENG HUANG,HONGZHUAN CHEN,QINGXIANG SONG
申请号：
US15897122
公开号：
US20180171000A1
申请日:
2018.02.14
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention discloses a reconstituted lipoprotein modified by monosialoteterahexosyl ganglioside, an application in preparing a drug carrier thereof, and an application in preparing a drug for treating or preventing a disease associated with Aβ deposition thereof. Specifically, the present invention discloses an application of an appropriate amount of monosialoteterahexosyl ganglioside in modifying the reconstituted lipoprotein to increase an affinity of the reconstituted lipoprotein with amyloid β-protein (Aβ), and facilitating clearance of Aβ. Meanwhile, the reconstituted lipoprotein modified by monosialoteterahexosyl ganglioside is used as a multi-mode nano carrier for preventing and treating central nervous system diseases, and particularly Alzheimers disease.
