The present disclosure relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, reducing the risk of, and delaying the onset of microbial infections in humans and animals.In some embodiments, the present disclosure provides a compound of Formula (I): or a tautomer thereof or a pharmaceutically acceptable salt of the compound or tautomer.本發明概括關於抗微生物化合物之領域及製造和使用彼之方法。該等化合物用於治療和預防人類和動物之微生物感染、降低該微生物感染之風險及延遲該微生物感染之發作。在一些實施態樣中，本發明提供式(I)化合物： 或其互變異構物或該化合物或互變異構物的醫藥上可接受之鹽。
