A dialysis system (150) is described. The system comprises: a dialyzer (20, 30); a plurality of flow devices including a blood pump (48) that is operable with the dialyzer; and a graphical user interface ("GUI", 160). The GUI enables an operator to begin a therapy running according to a prescription, monitor the therapy, receive status messages from the therapy and collect data for post-therapy analysis. The GUI is also configured to receive the prescription via a local or wide area mode of data communication.