SAWYERS, CHARLES,ULMERT, DAVID,LEWIS, JASON,EVANS, MICHAEL,LIJA, HANS
申请号：
CA2853705
公开号：
CA2853705A1
申请日:
2012.10.25
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention provides methods of monitoring and measuring tumor- associated free PSA ("fPSA") with antibody polypeptides as an indication of androgen receptor signaling. In a particular embodiment, the methods may be used to assess the efficacy of anti-androgen and/or general anti-cancer treatments. The present invention also provides various methods and compositions relating to antibodies that are specific for tumor- associated or intratumoral fPSA. For example, the present invention provides compositions, including pharmaceutical compositions, comprising anti-fPSA antibodies, or fragments or characterisitic portions thereof. The present invention further provides various therapeutic and/or diagnostic methods of using anti-fPSA antibodies and/or compositions.
