DE STAAT DER NEDERLANDEN; VERT. DOOR DE MINISTER VAN VWS; WELZIJN EN SPORT; MINISTERIE VAN VOLKSGEZONDHEID
发明人:
VAN DER LEY, PETER ANDRE,ARENAS BUSTO, JESUS ANDRES,PUPO ESCALONA, ELDER,TOMMASSEN, JOHANNES PETRUS MARIA
申请号：
CA3055757
公开号：
CA3055757A1
申请日:
2018.03.13
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The current invention lies in the field of medicine and more specifically in the field of vaccinology. The current invention concerns a novel Bordetella LPS and a modified bacterium of the genus Bordetella comprising such modified LPS. The LPS of the invention has a reduced endotoxicity in comparison to an unmodified Bordetella LPS. The modified LPS of the invention is therefore particularly suitable for use in inducing or stimulating an immune response in a subject, wherein the immune response is induced or stimulated against a Bordetella infection. The modified Bordetella LPS of the invention is obtainable by introducing in a Bordetellacell the expression of a heterologous acyl transferase. In particular, the modified Bordetella cell of the invention has an increased expression of an heterologous LpxA, LpxL or LpxD acyl transferase.
