The invention discloses substituent groups each in Formulas I to be defined in, such as (E) -3-methyl-N- [2- [(2-methyl-4-quinolyl amino] ethyl] but-1-ene-1-sulfonamide), these are intended as drug, are also suitble to application more specifically as the animal of drug. Drug can be preferably used for treatment invermination and treat parasitic disease for example because of the purposes of parasitic infection. It also discloses using compound, so that the method for drug and treatment invermination, prepares the method for the compound and pharmaceutical composition and kit comprising the compound.