ГХАЮР Тарик (US),ИСАКСОН Питер С. (US),ОЛСОН Лиза М. (US),ВУ Ченбин (US),ХЬЮГУНИН Маргарет (US),КАМАТХ Раджеш В. (US),КАФФ Кэролин А. (US),АЛЛЕН Хамиш Дж. (US)
申请号：
RU2010153580/10
公开号：
RU2010153580A
申请日:
2009.06.03
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. A binding protein comprising a polypeptide chain, where the specified polypeptide chain contains VD1- (X1) n-VD2-C- (X2) n, where! VD1 is the first variable domain of the heavy chain； ! VD2 is a second heavy chain variable domain； ! C represents a constant domain of the heavy chain； ! X1 is a linker, provided that it is not CH1； ! X2 is an Fc region； and! n is 0 or 1； ! where the specified binding protein has the ability to bind to a pair of antigens selected from the group consisting of TNF and IL-17A； TNF and RANKL； TNF and VEGF； TNF and SOST； TNF and DKK； TNF and alphaVbeta3； TNF and NGF； TNF and IL-23p19； TNF and IL-6； TNF and IL-6R； TNF and CD-20； IgE and IL-13； IL-13 and IL-23p19； IgE and IL-4； IgE and IL-9； IL-13 and IL-9； IL-13 and IL-4； IL-6R and VEGF； IL-6R and IL-17A； IL-6R and RANKL； IL-17A and IL-1 beta； IL-1 beta and RANKL； IL-1 beta and VEGF； RANKL and CD-20； and IL-1 alpha and IL-1 beta. ! 2. The binding protein according to claim 1, where VD1 and VD2 contain an amino acid sequence selected from the group consisting of SEQ ID NN: 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50 , 52, 54, 56, 58, 60, 62, 64, 66, 68 and 70.! 3. A binding protein comprising a polypeptide chain, wherein said polypeptide chain contains VD1- (X1) n-VD2-C- (X2) n, where! VD1 is the first variable domain of the light chain； ! VD2 is a second light chain variable domain； ! C represents a constant domain of the light chain； ! X1 is a linker, provided that it is not CH1； ! X2 does not contain an Fc region； and! n is 0 or 1； ! where the specified binding protein has the ability to bind to a pair of antigens selected from the group consisting of TNF and IL-17A； TNF and RANKL； TNF and VEGF； TNF and SOST； TNF and DKK； TNF and alphaVbeta3； TNF and NGF； TNF and IL-23p19； TNF and IL-6； TNF and IL-6R； TNF and CD-20； IgE and IL-13； IL-13 and IL-23p19； IgE and IL-4； IgE and IL-9； IL-13 and IL-9； IL-13 and IL-4； IL-6R and VEGF； IL-6R and IL-17A； IL-6R and RANKL； IL-17A and IL-1 b1. Связы
