Richard S. Blumberg,Vijay K. Kuchroo,Yu-Hwa Huang,Chen Zhu,Ana C. Anderson
申请号：
US14418726
公开号：
US20150225457A1
申请日:
2013.07.30
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Described herein are compositions and methods for the modulation of T-cell tolerance, which can be upregulated or down regulated by concurrent enhancement or inhibition of CEACAM1/TIM3 interactions. As described herein, the discovery that CEACAM1 is a direct ligand of TIM3 and vice versa has been shown in cis and in trans. In addition, as demonstrated herein, CEACAM1 and TIM3 are co-regulated during the course of T-cell activation.
