A biopsy instrument (1) is disclosed comprising a guide wire (2) arranged in a sheath (3), a drill device (5) arranged at a first end (4) of said guide wire (2), and an actuator (11) for actuating said drill device (5), said actuator being arranged at a second end (10) of said guide wire (2). The drill device (5) comprises an outer tube (6) and an inner cutting device (7). The inner cutting device (7) is slidable and rotatable inside said outer tube (6). The inner cutting device (7) has a helical cutting edge (8). An endoscope comprising such an endoscopic instrument (1) is also disclosed, as well as a method for taking a biopsy sample from a tissue of a subject.
