BROWN, MARC BARRY,STEVENSON, CAMERON ROBERT,EVANS, CHARLES RODNEY GREENAWAY
申请号：
CA2988289
公开号：
CA2988289A1
申请日:
2016.06.03
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Compositions for topical administration of a hedgehog inhibitor compound are described. In one embodiment, the hedgehog inhibitor compound is patidegib and the topical composition comprises the compound in a solvent system of a monohydric primary alcohol and a polyol in a w/w ratio of between about 0.9-1.8. In another embodiment, the hedgehog inhibitor is itraconazole and the topical composition comprises the compound in a solvent system comprising a monohydric primary alcohol and an optionally lower alkyl end-capped oligomeric alkylene glycol in a w/w ratio of between about 0.8 and 2.6 and a fused bicyclic ether. Method of using the compositions are also described, where in one embodiment, the compositions are topically applied for treating or preventing basal cell carcinoma.
