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RADIOTRACER, IN PARTICULAR FOR ALZHEIMER'S DISEASE
专利权人:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);UNIVERSITE DE LORRAINE
发明人:
CHAPLEUR, YVES,CHAPLEUR, Yves,LAMANDE-LANGLE, SANDRINE,LAMANDE-LANGLE, Sandrine,COLLET, CHARLOTTE,COLLET, Charlotte,CHRETIEN, FRANCOISE,CHRETIEN, Françoise
申请号:
EPEP2013/057143
公开号:
WO2013/150117A1
申请日:
2013.04.04
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
The invention relates to a compound of formula (I), where: n is an integer equal to 0 or 1; R1 is, when n=0, an alkyl chain having 3 to 6 carbon atoms, an alkenyl chain, alkylene, a linear hydroxyalkyl chain having 2 to 6 carbon atoms, the hydroxyl function optionally being protected or the oxygen of said function being substituted so as to form a leaving group, a halogenoalkyl chain having 2 to 6 carbon atoms, the halogen optionally being radioactive, or a fluoromethyl group, the fluorine optionally being radioactive, and when n=1, a monohydroxyalkyl chain having 1 to 6 carbon atoms, the hydroxyl function, at the terminal position, optionally being protected or the oxygen of said function being substituted so as to form a leaving group, or monohalogenoalkyl having 1 to 6 carbon atoms, the halogen at the terminal position optionally being radioactive, wherein the halogen is not bromine;P1 is, when n=0, hydrogen or a group protecting the hydroxyl function, identical or different, when n=1 and R1 is a monohydroxyalkyl chain, hydrogen or a group protecting the hydroxyl function, identical or different, and when n=1 and R1 is a monohalogenalkyl chain, hydrogen or a group protecting the hydroxyl function, identical or different; Y1 is, when n=0, an OP1 group, where P1 is as defined above, or, when n=1, a hydrogen atom, with the exception of the non-radiolabeled 2-fluoromethyl-myo-inositol compounds for which P1, identical or different, is a hydrogen atom or a benzyl protecting group, and to the use thereof as a drug.L'invention concerne un composé de formule (I) : dans laquelle n est un entier égal à 0 ou 1, R1 représente quand n=0, une chaîne alkyle de 3 à 6 atomes de carbone, une chaîne alkènyle, alkylène, une chaîne hydroxyalkyle linéaire de 2 à 6 atomes de carbone, la fonction hydroxyle étant éventuellement protégée ou l'oxygène de cette fonction étant substitué de manière à former un groupement partant, une chaîne halogénoalkyle, l'halogène étant radioactif ou non
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