Garrett-Thomson, Sarah C.,Almo, Steven C.,Seidel, Ronald D.
申请号：
AU2017266905
公开号：
AU2017266905A1
申请日:
2017.05.17
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
The present disclosure provides variant PD-L1 immunomodulatory polypeptides, and fusion polypeptides comprising the variant immunomodulatory peptides. The present disclosure provides T- cell modulatory multimeric polypeptides, and compositions comprising same, where the T-cell modulatory multimeric polypeptides comprise a variant immunomodulatory polypeptide of the present disclosure. The present disclosure provides nucleic acids comprising nucleotide sequences encoding the T-cell modulatory multimeric polypeptides, and host cells comprising the nucleic acids. The present disclosure provides methods of modulating the activity of a T cell； the methods comprise contacting the T cell with a T-cell modulatory multimeric polypeptide of the present disclosure.
