The invention relates to a method and a data processing device for evaluating measurement signals provided by a layered, pixelated radiation detector. A generalized detector response function is provided that describes the energy-related crosstalk caused by radiation incident in the d-th neighboring pixel. With the help of this GDR-function, crosstalk effects can be taken into account to achieve a more accurate determination of imaging parameters related to an imaged object. The approach can particularly be used in spectrally resolved, photon counting CT detectors with small, layered pixels.