Heath M. Guay;Margot O'Toole;Sadhana Jain;Maya Arai;Yulia Vugmeyster;Deborah A. Young;Davinder Gill;Karissa K. Adkins;Amy Arlene Weaver;Laird Bloom
发明人:
Laird Bloom,Davinder Gill,Yulia Vugmeyster,Deborah A. Young,Margot O'Toole,Heath M. Guay,Karissa K. Adkins,Amy Arlene Weaver,Sadhana Jain,Maya Arai,Margot OToole
申请号：
US12472237
公开号：
US08178097B2
申请日:
2009.05.26
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides binding proteins and antigen-binding fragments thereof, including human antibodies, that specifically bind to the human interleukin-21 receptor (IL-21R), and methods of using them. The binding proteins can act as, e.g., antagonists of IL-21R activity, thereby modulating immune responses in general, and those mediated by IL-21R in particular. The disclosed compositions and methods may be used, e.g., in diagnosing, treating, and/or preventing IL-21R-associated disorders, e.g., inflammatory disorders, autoimmune diseases, allergies, transplant rejection, and other immune system disorders.
