Ultrasound imaging systems for automatically adjusting settings according to an position and/or orientation of one or more interfaces. The ultrasound imaging systems can include a probe configured to send and receive ultrasound signals for performing a medical exam, a medical procedure, or both； and a processor configured to: select a diagnostics mode or a procedural mode based on an operating orientation of the ultrasound imaging system or a portion thereof, and adjust one or more settings of the imaging system according to the selected diagnostics mode or the selected procedural mode.
