Described herein are compounds comprising modified oligonucleotides that are complementary to miR-103 and/or miR-107 and methods of treating diseases and disorders using the compounds.在此描述了包括修飾的寡核苷酸之化合物,該修飾的寡核苷酸與miR-103和/或miR-107互補,以及使用該等化合物治療疾病和失調之方法。