Embodiments provide an endoluminal prosthesis deployment system and method for deploying the prosthesis for cannulation of branch vessels. The prosthesis can include an anterior fenestration (29) and a posterior opening (96). A guide can be disposed to exit the prosthesis lumen through a lateral fenestration, enter through the anterior fenestration (29), and exit the prosthesis lumen through the posterior opening (96). A sheath can be preloaded over the branch wire at the lateral fenestration for vessel cannulation, such as in renal arteries. The sheath can include another branch wire that extends from the lateral fenestration to another lateral fenestration. An end of the guide can be retracted after partial expansion of the prosthesis, and another sheath can be inserted over the retracted guide and moved through the posterior opening (96) and to the anterior fenestration (29). A separate branch guide wire can then be directed through the sheath for vessel cannulation, such as the SMA.
