XUAN, Mengyang,FORICHER, Yann,DE HARO GARCIA, Teresa,JOHNSON, James Andrew,ZHU, Zhaoning,HORSLEY, Helen Tracey,MACCOSS, Malcolm,HUTCHINGS, Martin Clive,BROOKINGS, Daniel Christopher
申请号：
CR20190526
公开号：
CR20190526A
申请日:
2018.04.24
申请国别(地区):
CR
年份:
2020
代理人:
摘要：
A formula compound (I) or a pharmaceutically acceptable salt defined in the explanatory report, as a powerful modulator of human TNFa activity, is therefore beneficial to the treatment and / or prevention of various human diseases, Including self immunity and inflammation； neurodegenerative disorders； pain and harmful disorders； cardiovascular disorders； metabolic disorders； eye disorders； and tumor disorders, such as formula (I) deficiency or acceptable salinization, Being potent modulators of human TNFA activity，Are accordingly of benefit in the treatment and/or prevention of various human ailments，including autimmune and inflammatory disorders；neurological and neurgenerative disorders；pain and discipptive disorders；cardiovascular disorders；metabolic disorders；obligo disorders；and oncological disorders.Un compuesto de fórmula (I) como se define en la memoria descriptiva, o una sal farmacéuticamente aceptable del mismo, como moduladores potentes de la actividad de TNFa humano, los cuales por consiguiente son beneficiosos para el tratamiento y/o la prevención de diversas enfermedades humanas, incluyendo trastornos autoinmunológicos e inflamatorios； trastornos neurológicos y neurodegenerativos； dolor y trastornos nociceptivos； trastornos cardiovasculares； trastornos metabólicos； trastornos oculares； y trastornos oncológicos.A compound of formula (I) as defined herein, or a pharmaceutically acceptable salt thereof, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders； neurological and neurodegenerative disorders； pain and nociceptive disorders； cardiovascular disorders； metabolic disorders； ocular disorders； and oncological disorders.
