Catheter clamp assembly (10) having a base (12) and a slide cover (14). The base has a top (16), bottom (18) and a body (20) including a slide cover track (22). The body has internal walls (24) defining a catheter opening (26) extending from the bottom to the top. A catheter channel (28) extends from the catheter opening to a sidewall opening (30). The slide cover includes a lower surface (36) incorporating a prong (34) to engage a wall defining the catheter opening and to secure a catheter (104) in the catheter channel. The slide cover has a first location providing access to the catheter opening and a second location that clamps a catheter in the catheter channel. Moving the slide cover from its first location contacts a length of catheter to position it in the catheter channel for securement when the slide cover reaches its second location.