The invention relates to Proprotein Convertase Subtilisin Kexin type 9 (PCSK9) antagonists, such as antibodies and fragments, as well as methods, uses and combinations.L'invention concerne des antagonistes de la proprotéine convertase subtilisine/kexine de type 9 (PCSK9), tels que des anticorps et des fragments, ainsi que des méthodes, des utilisations et des associations.