Piggy back delivery of nucleic acids into organisms

• 收藏
• 分享

专利权人:

发明人:

Pudur Jagadeeswaran

申请号：

US14714423

公开号：

US09453223B2

申请日:

2015.05.18

申请国别(地区):

US

年份:

2016

代理人:

摘要：

The present invention includes nucleic acid hybrid molecules capable of entering cells comprising at least one vivo-morpholino oligonucleotide (vivo-MO) comprising a guanidine-rich head conjugated to the 5′ end, and at least one standard oligonucleotide comprising a gene-specific sequence and a standard oligonucleotide pairing sequence, wherein the standard oligonucleotide is bound to the vivo-morpholino oligonucleotide through base pairing to form a hybrid and wherein the vivo-morpholino oligonucleotide pairing sequence is complementary to the standard oligonucleotide pairing sequence.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/