Nagy Mahmoud Hassan Khalifa,Mohamed A. Al-Omar,Hamad M. Alkahtani,Ahmed H. Bakheit
申请号：
US15944734
公开号：
US10100054B1
申请日:
2018.04.03
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The pyrido[2,3-d]pyrimidine derivatives as anticancer agents include 5-(substituted-phenyl)-2-(3-methyl-5-oxo-2H-pyrazol-1(5H)-yl)-7-(pyridin-3-yl)pyrido[2,3-d]pyrimidin-4(3H)-one derivatives having the formula:where R is hydrogen 2-halo, 3-halo, or 4-halo (Cl, Br, or F) 2-methoxy, 3-methoxy, or 4-methoxy (OCH3) 2-nitro, 3-nitro, or 4-nitro (NO2) 4-isopropyl, 4-methyl, or 4-cyano (CN) 2-hydroxy or 3-hydroxy (OH), 3-chloro and 5-chloro 2-methoxy and 5-methoxy, 3-methoxy and 5-methoxy, or 3-methoxy and 4-methoxy 3,4,5-trimethoxy or 2-hydroxy and 4-hydroxy or a pharmaceutically acceptable salt thereof. The derivatives may be useful in treating various cancers, including hepatic, colon, prostate, breast, and lung cancer.
