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METHODS FOR THE MODULATION OF ANGIOGENESIS
专利权人:
THE CHILDREN'S MEDICAL CENTER CORPORATION
发明人:
Donald E. INGBER,Akiko MAMMOTO
申请号:
US14226179
公开号:
US20140303234A1
申请日:
2014.03.26
申请国别(地区):
US
年份:
2014
代理人:
摘要:
The present invention relates to methods and compositions for promoting or inhibiting capillary endothelial (CE) cell migration, promoting or inhibiting the formation of CE networks and promoting or inhibiting angiogenesis. Some embodiments relate to methods and compositions for treating angiogenesis-related disorders characterized by loss or decreased angiogenesis. One aspect relates to the use of at least one pro-angiogenic agent selected from at least one of an p190RhoGAP inhibitor, a TFII-I inhibitor a GATA-2 activator for promoting the formation of CE networks and angiogenesis, and methods for treating angiogenesis-related disorders characterized by loss or decreased angiogenesis. Another aspect of the invention related to use of at least one anti-angiogenic agent selected from at least one of an p190RhoGAP activator, a TFII-I activator a GATA-2 inhibitor for inhibiting the formation of CE networks and inhibiting angiogenesis, and methods for treating angiogenesis-related disorders characterized by uncontrolled or elevated angiogenesis.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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