THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人:
STOCKWELL, BRENT R.,WELSCH, MATTHEW
申请号：
CA2950581
公开号：
CA2950581A1
申请日:
2015.05.29
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The present invention provides, inter alia, compounds that selectively bind a RAS protein at two or more sites and methods for their synthesis. Compositions and kits containing the compounds, as well as methods of using the compounds and compositions for ameliorating or treating the effects of a disease associated with altered RAS signaling, such as a cancer, in a subject and methods for effecting cancer cell death are also provided herein. Methods of identifying a multivalent compound which binds selectively to a target protein also are provided herein.
