YARRANTON, Geoffrey T.,PALATH, Varghese,BEBBINGTON, Christopher R.,BAER, Mark
申请号：
USUS2012/050262
公开号：
WO2013/025467A3
申请日:
2012.08.10
申请国别(地区):
WO
年份:
2014
代理人:
摘要：
The disclosure provides diagnostic and therapeutic methods for the treatment of hematological proliferative disorders. Specifically, the disclosure is based on the discovery that vasculature in bone marrow from patients having a hematological proliferative disorder expresses EphA3. Agents that target EphA3, such as activating EphA3 antibodies, can be employed for the treatment of hematological proliferative disorders in patients where the neoplastic cells themselves do not express EphA3, or express low levels of EphA3. Further disclosed are the types of hematological proliferative disorders can be treated by the methods disclosed.La présente invention concerne des méthodes de diagnostic et de thérapie dans le traitement de troubles prolifératifs hématologiques.
