MEMORIAL SLOAN-KETTERING CANCER CENTER;THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HE
发明人:
Michel Sadelain,Reuben Benjamin,Dimiter S. Dimitrov,Yang Feng
申请号：
US15884608
公开号：
US20180230214A1
申请日:
2018.01.31
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The presently disclosed subject matter provides for methods and compositions for treating cancer (e.g., multiple myeloma). It relates to anti-CD56 antibodies, chimeric antigen receptors (CARs) that specifically target human CD56, and immunoresponsive cells comprising such CARs. The presently disclosed CD56-specific CARs have enhanced immune-activating properties, including anti-tumor activity.
