FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to field of pharmacy and represents microsphere with controlled release, which has covering layer and contains core, which contains exendin as active ingredient and biodegradable polymer, and covering layer, which covers core with covering material, exendin being exendin-4 (SEQ ID NO:2), biodegradable polymer represents polymer, selected from group, consisting of polylactide (PLA), polyglycolide (PGA), lactide and glycolide copolymer (PLGA), polyorthoester, polyanhydride, polyhydroxybutyric acid, polycaprolactone and polyalkylcarbonate； copolymer or simple mixture of two or more polymers, selected from said group of polymers； copolymer of said polymer and polyethylene glycol (PEG)； or polymer-sugar complex, in which sugar is bound with said polymer or said copolymer, covering material is selected from group, consisting of essential amino acids, polypeptides and organic nitrogenous compounds, essential amino acid being one or more, selected from group, consisting of arginine, lysine and histidine； polypeptide represents L-Lys-L-Thr-L-Thr-L-Lys-L-Ser； and organic nitrogenous compound is selected from group, consisting of creatine, creatinine and urea, content of covering layer constitutes from 0.01 to 5 wt fractions in terms per 100 wt fractions of microsphere.EFFECT: invention ensures increase of bioaccessability and reduction of initial peak of exendin for prevention of such side effects as vomiting, nausea, headache.10 cl, 7 ex, 5 tbl, 7 dwgИзобретение относится к области фармации и представляет собой микросферу с контролируемым высвобождением, имеющую покровный слой и содержащую ядро, содержащее экзендин в качестве активного ингредиента и биоразлагающийся полимер, и покровный слой, который покрывает ядро покрывающим материалом, при этом экзендин является экзендином-4 (SEQ ID NO:2), биоразлагающийся полимер представляет собой полимер, выбранный из группы, состоящей из полилактида (PLA), полигликолида (PG
