As for this invention, being the cancer remedy which designates substance and especially CRM197 which obstruct the connection with HB-EGF and the EGF receptor by connecting to HB-EGF as the active ingredient, the cancer the bladder cancer and the colon cancer, or, is chosen from the group which consists of the peritoneum seeding transfer cancer of the stomach cancer and the cancer, the cancer remedy is offered.本発明は、HB-EGFに結合することによりHB-EGFとEGFレセプターとの結合を阻害する物質、特にCRM197を有効成分とする癌治療薬であって、癌が膀胱癌、大腸癌、あるいは、胃癌と膵癌の腹膜播種転移癌からなる群から選ばれる、癌治療薬を提供する。
