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ЛИПОСОМАЛЬНЫЙ ПРЕПАРАТ ДАЛЦЕТРАПИБА
专利权人:
Ф. ХОФФМАНН-ЛЯ РОШ АГ (CH)
发明人:
ГРОСС Гюнтер (DE),ТАРДИО Жозеф (FR)
申请号:
RU2013129777/15
公开号:
RU2013129777A
申请日:
2011.12.05
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A composition comprising S- [2 - ([[1- (2-ethylbutyl) cyclohexyl] carbonyl] amino) phenyl] 2-methylpropanethioate and liposomes, where S- [2- ([[1- (2-ethylbutyl ) -cyclohexyl] carbonyl] amino) phenyl] 2-methylpropanethioate is substantially enclosed in the liposome membrane. The composition of claim 1, wherein at least 95% of 8- [2 - ([[1- (2-ethylbutyl) -cyclohexyl] carbonyl] amino) phenyl] 2-methylpropanethioate is encapsulated in the liposome. The composition of claim 1, wherein 100% of S- [2 - ([[1- (2-ethylbutyl) -cyclohexyl] carbonyl] amino) phenyl] 2-methylpropanethioate is encapsulated in the liposome. The composition of claim 1, wherein the liposomes have sizes from 20 to 1000 nm, in particular from 25 to 200 nm. The composition of claim 1, wherein about 80%, more specifically 95% of the liposomes have sizes from about 25 to about 200 nm. The composition of claim 1, wherein the liposome is a vesicle with a membrane containing a phospholipid bilayer. 7. The composition of claim 1, wherein the liposome is a spherical vesicle with a membrane containing a phospholipid bilayer. The composition of claim 1, wherein the liposomes are phospholipids. The composition of claim 1, wherein the phospholipids are selected from one or more phospholipids from the group consisting of egg phosphatidylethanolamine, egg lecithin, dipalmitoyllecithin, lecithin, egg phosphatidylcholine, dioleoylphosphatidylcholine, 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphatidylcholine , dipalmitoylphosphatidylcholine, dimyristoylphosphatidylcholine and / or long-chain phosphatidylcholine or phosphatidylcholine with an intermediate chain length. The composition of claim 1, wherein the phospholipids are lecithins. The composition of claim 1, wherein the lecithins are of plant, animal or synthetic origin. The composition of claim 1, wherein the lecithins are wherein the liposome is a spherical vesicle with a membrane containing a phospholipid bilayer. The composition of claim 1, wherein the lipo
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