The present invention relates to a process for the preparation of an extract comprising a mixture of madecassoside, of terminoloside and, where appropriate, of asiaticoside, an extract of Centella Asiatica comprising more than 75% by mass of a mixture of madecassoside, of terminoloside and of asiaticoside, relative to the total weight of the extract, an extract of Centella asiatica comprising more than 95% by mass of a mixture of madecassoside and terminoloside relative to the total weight of the extract and their use in regulation inflammatory mechanisms.La présente invention concerne un procédé de préparation d~un extraitcomprenant un mélange de madécassoside, de terminoloside et le cas échéantd~asiaticoside, un extrait de Centella Asiatica comprenant plus de 75% enmasse d~un mélange de madécassoside, de terminoloside et d~asiaticoside, parrapport au poids total de l~extrait, un extrait de Centella asiaticacomprenant plus de 95% en masse d~un mélange de madécassoside et determinoloside par rapport au poids total de l~extrait et leur utilisation dansla régulation des mécanismes inflammatoires.