Cosmetic method, external preparation for skin used therefor, migration imparting agent, screening method for ingredients used in cosmetic method for improving skin condition
The present invention relates to a cosmetic method for improving the skin condition by causing fat-derived stem cells to migrate to the dermis layer by applying an agent for imparting migration of fat-derived stem cells to the skin. The present invention also relates to a skin external preparation for use in the cosmetic method, which contains a migration imparting agent that causes fat-derived stem cells to migrate to the dermis layer when applied to the skin. The present invention further relates to an agent for imparting migration of adipose-derived stem cells, which contains at least one of a polyol compound and a hydrophilic biological substance. The present invention further relates to a screening method for components used in a cosmetic method for improving skin condition, comprising a step of evaluating the migration activity of adipose-derived stem cells using a preparation medium containing a sample.本発明は、脂肪由来幹細胞の遊走付与剤を皮膚に適用することにより、脂肪由来幹細胞を真皮層に遊走させ、皮膚状態を向上させる美容方法に関する。本発明はまた、上記美容方法に用いられる皮膚外用剤であって、皮膚への適用によって脂肪由来幹細胞を真皮層に遊走させる遊走付与剤を含有することを特徴とする皮膚外用剤にも関する。本発明はさらに、ポリオール化合物および親水性生体物質の少なくとも一種を含有する脂肪由来幹細胞の遊走付与剤にも関する。本発明はさらにまた、試料を含有する調製培地を用いて、脂肪由来幹細胞の遊走活性を評価する工程を包含する、皮膚状態を向上させる美容方法に用いられる成分のスクリーニング方法にも関する。
