The present application is directed to an image-guided vacuum assisted,percutaneous, coring cable driven breast biopsy instrument (40) which may beconveniently mounted to an x-ray machine wherein the biopsy instrument (40)incorporates a rotation knob (45) at the proximal end of the instrument tomanually rotate the distal end of the probe, thus allowing the clinician toconveniently position the tissue port next to the tissue to be sampled.
