The present disclosure relates to compositions and methods for acceleratingthe healing process of wounds, increasing the closure of skin wounds, and decreasinginflammation at the site of a skin wound. Specifically, the disclosure relatesto compositions comprising a delta-PKC activator, an alpha-PKC inhibitor,and a pharmaceutically acceptable carrier that is free of Ca andMg cations. The disclosure also relates to compositions comprisingan insulin or insulin analog and a pharmaceutically acceptable carrier thatis free of Ca and Mg cation
