SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES;THE UNIVERSTIY OF CHICAGO
发明人:
Chuan HE,Jing WANG,Hualiang JIANG,Cheng LUO,Hong LIU,Junyan LU
申请号：
US14762980
公开号：
US20160074373A1
申请日:
2014.01.23
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Compositions and methods concern organic molecules that bind to human Atox1 and CCS at the copper trafficking interface of these proteins. This binding suppresses copper trafficking, which leads to inhibition of cancer cell proliferation and tumor growth. In addition to serving as an effective treatment of cancer, these organic molecules inhibit cellular copper uptake and can be used as treatment of disorders of copper metabolism such as Wilson's disease, which is characterized by copper overload, as well as wound healing.
