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Use of benzylideneaminoguanidines and hydroxyguanidines as melanocortin receptor ligands
专利权人:
Torbjörn Lundstedt;Elisabeth Seifert;Anna Skottner
发明人:
Torbjörn Lundstedt,Anna Skottner,Elisabeth Seifert
申请号:
US12892402
公开号:
US08309609B2
申请日:
2010.09.28
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention relates to the use of compounds of general formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system: wherein X is H or OH; R1, R2, R3, R4 and R5 are the same or different and are selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, electron donor groups such as alkoxy having 1-5 carbon atoms or hydroxy, electron acceptor groups selected from cyano, nitro, trifluoroalkyl or amide; alkylamino, benzoyloxy, nitroxy, phenyl or sulpho; and the pharmacologically active salts thereof.
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