Shanghai Institute of Materia Medica; Chinese Academy of Sciences
发明人:
Jianhua Shen,Yiping Wang,Xinde Chen,Wenwei Xu,Kai Wang
申请号：
US16299636
公开号：
US20190248751A1
申请日:
2019.03.12
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention relates to pyrimidone compounds used as Lp-PLA2 inhibitors and pharmaceutical compositions thereof. The structure of the pyrimidone compounds is represented by general formula (I), wherein R1, R2, R3, X, Ar, Y and n are defined as in the specification and claims. The compounds of general formula (I) in the present invention, stereoisomers and pharmaceutically acceptable salts thereof can be used as Lp-PLA2 inhibitors for preventing, treating and/or ameliorating diseases associated with the activity of Lp-PLA2 enzyme.
