Provision of compounds capable of treating and / or preventing diseases associated with 7 receptor 5HT, is used for preventing migraine and / or treatment of irritable bowel syndrome (IBS) and in particular present invention relates 5HT 2B receptor. It has been found that acceptable salt thereof or a pharmaceutically acyl guanidine derivatives characterized by having [SOLUTION] tricyclic structure has a strong antagonism to 7 receptors 5HT and 5HT 2B receptor. The present invention compounds with antagonistic activity on both receptors showed a good pharmacological action in comparison with the case of using alone antagonist selective for one receptor, respectively. From the above, the prevention and / or treatment of diseases involving 7 receptors 5HT and 5HT 2B receptor, the compounds of the present invention are useful for the prevention of migraine and / or treatment of irritable bowel syndrome (IBS), especially .【課題】5HT2B受容体及び5HT7受容体が関与する疾患の予防及び/または治療、特に過敏性腸症候群(IBS)の治療及び/または片頭痛の予防に用いることができる化合物の提供。【解決手段】三環系構造を有することを特徴とするアシルグアニジン誘導体またはその製薬学的に許容される塩が5HT2B受容体及び5HT7受容体に強力な拮抗作用を有することを見出した。また、両受容体に拮抗活性を有する本発明化合物はそれぞれ一方の受容体に選択的な拮抗薬を単独で用いた場合と比較して良好な薬理作用を示した。以上のことから、本発明化合物は5HT2B受容体及び5HT7受容体が関与する疾患の予防及び/または治療、特に過敏性腸症候群(IBS)の治療及び/または片頭痛の予防に有用である。
